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Drugs and Medicinal Substances

Streptomycin

Antiinfective Agents for Systemic Use

Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever.

Facts
Drug Class
Aminoglycoside antibiotic 1
Mechanism of Action
Blocks bacterial protein synthesis by binding irreversibly to the 30S ribosomal subunit, causing codon misreading that leads to cell death. 1
Approved Use
Treats tuberculosis and other bacterial infections including Mycobacterium avium complex, endocarditis, brucellosis, plague and tularemia. 1
First Approved / Isolated Year
1943 1
Significant Risk
Vertigo, vomiting, facial numbness, fever and rash; may cause permanent deafness in a developing fetus during pregnancy. 1
Classification
Approval Status
Approved 1
ATC ClassSourced to the subject's own account
J: Antiinfectives for Systemic Use 2
Route of Administration
Intravenous 3
WHO Essential MedicineSourced to the subject's own account
Core List 4
Connections

Associated With

Antibiotics, Treatments
Discovery of Streptomycin, Discoveries

Discovered By

Albert Schatz, Healers
Source Streptomycin (Wikipedia)
Selman Waksman, Healers
Source Streptomycin (Wikipedia)

Treats

Tuberculosis, Conditions
Source Streptomycin (Wikipedia)
Sources
1. Streptomycin (Wikipedia)
Wikimedia Foundation
  • Lead section
    tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis
  • Infobox, drug class
    Aminoglycoside antibiotic
  • Mechanism of action section
    binding to the 30S ribosomal subunit
  • History section
    First isolated on October 19, 1943, by Albert Schatz in Selman Abraham Waksman laboratory at Rutgers University
  • Adverse effects section
    Common side effects include vertigo, vomiting, numbness of the face, fever, and rash
  • Regulatory approval status
View the Source
2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code J
Quote, First-level anatomical group codes, Code J
Antiinfectives for systemic use
View the Source
3. Wikipedia
Wikipedia contributors, Wikimedia Foundationhttps://en.wikipedia.org/wiki/Streptomycin, lead section
Quote, https://en.wikipedia.org/wiki/Streptomycin, lead section
fampicin, and pyrazinamide. It is administered by injection into a vein or muscle.
View the Source
4. WHO Model List of Essential Medicines (Wikipedia)
WikipediaWHO Model List of Essential Medicines, Antituberculosis medicines section
Quote, WHO Model List of Essential Medicines, Antituberculosis medicines section
Streptomycin
View the Source
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