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Drugs and Medicinal Substances

Quinine

Antiinfective Agents for Systemic Use

Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available.

Facts
Drug Class
Antimalarial alkaloid 1
Mechanism of Action
Interferes with the malaria parasite ability to metabolize hemoglobin, likely by inhibiting hemozoin biocrystallization in the heme detoxification pathway, causing toxic heme accumulation. 1
Approved Use
Treats malaria, including chloroquine-resistant Plasmodium falciparum, and babesiosis. 1
First Approved / Isolated Year
1820 1
Significant Risk
Headache, tinnitus, vision problems and sweating; severe effects can include deafness, low blood platelets and irregular heartbeat. 1
Classification
Approval Status
Approved 1
ATC ClassSourced to the subject's own account
J: Antiinfectives for Systemic Use 2
Route of Administration
Oral 3
WHO Essential MedicineSourced to the subject's own account
Core List 4
Connections

Treats

Malaria, Conditions
Source Quinine (Wikipedia)
Sources
1. Quinine (Wikipedia)
Wikimedia Foundation
  • Lead section
    treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine
  • Infobox
    an alkaloid, a naturally occurring chemical compound
  • Mechanism of action section
    This model involves the inhibition of hemozoin biocrystallization in the heme detoxification pathway, which facilitates the aggregation of cytotoxic heme.
  • History section
    In 1820, French researchers Pierre Joseph Pelletier and Joseph Bienaimé Caventou first isolated quinine from the bark of a tree in the genus Cinchona - probably Cinchona pubescens - and subsequently named the substance.
  • Adverse effects section
    Common side effects include headache, ringing in the ears, vision issues, and sweating
  • https://en.wikipedia.org/wiki/Quinine, lead section
    se due to the risk of serious side effects. It can be taken by mouth or intravenously. Malaria resistance to quinine occurs in certain areas of the world. Quinine is also used as an ingredient in tonic water and other beverages to impart a bitter taste.
  • Regulatory approval status
View the Source
2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code J
Quote, First-level anatomical group codes, Code J
Antiinfectives for systemic use
View the Source
3. Wikipedia
Wikipedia contributors, Wikimedia Foundation
4. WHO Model List of Essential Medicines (Wikipedia)
WikipediaWHO Model List of Essential Medicines, Medicines for curative treatment section
Quote, WHO Model List of Essential Medicines, Medicines for curative treatment section
Quinine
View the Source
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