Procarbazine is a chemotherapy medication used to treat Hodgkin lymphoma and certain brain cancers. It belongs to the alkylating agent family of drugs, though its precise mechanism is not fully understood; it is thought to work in part by methylating guanine in DNA, causing strand breaks that trigger the death of cancer cells. Procarbazine was approved for medical use in the United States in 1969 and appears on the World Health Organization's List of Essential Medicines, and is typically taken orally.
Facts
Mechanism of ActionMethylates guanine at the O-6 position, causing DNA strand breakage and inhibiting RNA and protein synthesis 1 Approved UseUsed for the treatment of Hodgkin lymphoma and certain brain cancers 1 First Approved / Isolated Year Significant RiskUse in pregnancy is known to harm the baby, alongside common effects of low blood cell counts and vomiting 1 Classification
Approval Status ATC ClassSourced to the subject's own accountL: Antineoplastic and Immunomodulating Agents 2 Route of Administration WHO Essential MedicineSourced to the subject's own account Connections
Sources
1. Procarbazine (Wikipedia)
Lead section
Procarbazine is in the alkylating agents family of medication
Pharmacology section
Procarbazine works, in part, as an alkylating agent and methylates guanine at the O-6 position
Lead section, uses sentence
Used for the treatment of Hodgkin lymphoma and brain cancers
Lead section, approval sentence
Procarbazine was approved for medical use in the United States in 1969
Lead section, pregnancy sentence
Use in pregnancy is known to harm the baby
https://en.wikipedia.org/wiki/Procarbazine, lead section
used with lomustine and vincristine. It is typically taken by mouth.
- Regulatory approval status
View the Source2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code LQuote, First-level anatomical group codes, Code L
Antineoplastic and immunomodulating agents
3. Wikipedia
Wikipedia contributors, Wikimedia Foundation
4. WHO Model List of Essential Medicines (Wikipedia)
WikipediaWHO Model List of Essential Medicines, Cytotoxic medicines sectionQuote, WHO Model List of Essential Medicines, Cytotoxic medicines section
Procarbazine
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