Vinorelbine, sold under the brand name Navelbine, is a chemotherapy medication belonging to the vinca alkaloid family of drugs. It treats breast cancer and non small cell lung cancer by disrupting microtubules, which halts the division of cancer cells. The drug received United States approval in December 1994 and appears on the World Health Organization's List of Essential Medicines. Its common side effects include bone marrow suppression, pain at the injection site, vomiting, fatigue, numbness, and diarrhea, with respiratory distress as a possible serious effect.
Facts
Mechanism of ActionDisrupts microtubule function, stopping cancer cell division 1 Approved UseApproved in the United States for non-small-cell lung cancer; used for breast cancer as well in most European countries 1 First Approved / Isolated Year Significant RiskCommon side effects include bone marrow suppression, injection-site pain, vomiting, fatigue, numbness and diarrhea 1 Classification
Approval Status ATC ClassSourced to the subject's own accountL: Antineoplastic and Immunomodulating Agents 2 Route of Administration WHO Essential MedicineSourced to the subject's own account Connections
Sources
1. Vinorelbine (Wikipedia)
Lead section
Vinorelbine is in the vinca alkaloid family of medications.
Lead section, mechanism sentence
It is believed to work by disrupting the normal function of microtubules and thereby stopping cell division.
Medical uses section
Vinorelbine is approved for the treatment of non-small-cell lung cancer.
History section
Vinorelbine received approval by the United States Food and Drug Administration (FDA) in December 1994
Lead section, side effects sentence
Common side effects include bone marrow suppression, pain at the site of injection, vomiting, feeling tired, numbness, and diarrhea.
https://en.wikipedia.org/wiki/Vinorelbine, lead section
er and non-small cell lung cancer. It is given by injection into a vein or by mouth.
- Regulatory approval status
View the Source2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code LQuote, First-level anatomical group codes, Code L
Antineoplastic and immunomodulating agents
3. Wikipedia
Wikipedia contributors, Wikimedia Foundation
4. WHO Model List of Essential Medicines (Wikipedia)
WikipediaWHO Model List of Essential Medicines, Cytotoxic medicines sectionQuote, WHO Model List of Essential Medicines, Cytotoxic medicines section
Vinorelbine
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