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Drugs and Medicinal Substances

Furosemide

Cardiovascular System Agents

Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease.

Facts
Drug Class
Loop diuretic 1
Mechanism of Action
Inhibits the Na-K-Cl cotransporter in the thick ascending limb of the loop of Henle, increasing excretion of sodium, chloride and potassium. 1
Approved Use
Treats edema due to heart failure, liver scarring, or kidney disease. 1
First Approved / Isolated Year
1964 1
Significant Risk
Orthostatic hypotension, tinnitus and photosensitivity; potentially serious electrolyte abnormalities, low blood pressure and hearing loss. 1
Classification
Approval Status
Approved 1
ATC ClassSourced to the subject's own account
C: Cardiovascular System 2
Route of Administration
Intravenous 3
WHO Essential MedicineSourced to the subject's own account
Core List 4
Connections

Treats

Cardiovascular Disease, Conditions
Source Furosemide (Wikipedia)
Chronic Kidney Disease, Conditions
Source Furosemide (Wikipedia)
Sources
1. Furosemide (Wikipedia)
Wikimedia Foundation
  • Lead section
    used to treat edema due to heart failure, liver scarring, or kidney disease
  • Infobox, drug class
    Loop diuretic medication
  • Mechanism of action section
    inhibits the Na-K-Cl cotransporter in the thick ascending limb of the loop of Henle
  • History section
    1964
  • Adverse effects section
    Common side effects include orthostatic hypotension, tinnitus, and photosensitivity
  • Regulatory approval status
View the Source
2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code C
Quote, First-level anatomical group codes, Code C
Cardiovascular system
View the Source
3. Wikipedia
Wikipedia contributors, Wikimedia Foundationhttps://en.wikipedia.org/wiki/Furosemide, lead section
Quote, https://en.wikipedia.org/wiki/Furosemide, lead section
ood pressure. It can be taken intravenously or orally. When given intravenously, furosemide typically takes effect within five minutes; when taken orally, it typically metabolizes within an hour.
View the Source
4. WHO Model List of Essential Medicines (Wikipedia)
WikipediaWHO Model List of Essential Medicines, Diuretics section
Quote, WHO Model List of Essential Medicines, Diuretics section
Furosemide
View the Source
Frequently Asked Questions

What is furosemide used for, and what are its main risks?

A loop diuretic for edema; it can lower potassium and has been associated with hearing damage.

Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. The tendency, as for all loop diuretics, to cause low serum potassium concentration (hypokalemia) has given rise to combination products. Furosemide has been associated with ototoxicity in post-marketing reports and observational studies. This record describes what the sources state and is not medical advice.

When was furosemide approved, and why is it on the anti-doping list?

Approved in 1964; banned in sport because of masking concerns.

Furosemide was patented in 1959 and approved for medical use in 1964. It is on the World Health Organization's List of Essential Medicines. The substance appears on the World Anti-Doping Agency's banned list due to masking concerns.
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