Alcohol intolerance results from a genetic polymorphism of the aldehyde dehydrogenase enzyme, which is responsible for metabolizing acetaldehyde, and is most often reported in people of East Asian descent. It can also arise as a side effect of certain drugs, such as disulfiram, metronidazole, or nilutamide. Skin flushing and nasal congestion are its most common symptoms after alcohol is ingested, and it may also produce hangover-like symptoms resembling the disulfiram reaction of aldehyde dehydrogenase deficiency or chronic fatigue syndrome, with severe pain after drinking possibly indicating a more serious underlying condition.
Facts
Classification
ICD-10 ChapterIV: Endocrine, Nutritional and Metabolic Diseases 1 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) Sources
1. Wikipedia: ICD-10
WikipediaList of chapters, Chapter IVQuote, List of chapters, Chapter IV
Endocrine, nutritional and metabolic diseases
2. World Health Organization: Noncommunicable diseases (fact sheet)
World Health OrganizationLead section, transmission-route statement (inferred from disease-category)
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
Main Types section
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
View the Source 3. Alcohol intolerance (Wikipedia)
lead sentence 1Quote, lead sentence 1
Alcohol intolerance is due to a genetic polymorphism of the aldehyde dehydrogenase enzyme, which is responsible for the metabolism of acetaldehyde (produced from the metabolism of alcohol by alcohol dehydrogenase).
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