Dorsal pancreatic agenesis is a congenital anomaly in which the body and tail of the pancreas and the duct of Santorini are absent. It is regarded as asymptomatic, and the symptom most often seen is non-specific abdominal pain. The cause is unclear, but it is thought to arise from impaired dorsal buds or from mutation of genes that regulate organ formation in the embryo. Historically it was found by laparotomy or autopsy, and in recent years CT scanning combined with ERCP has been used to diagnose it. No specific drug is needed, though pancreatic enzyme capsules and insulin may be given. It is linked with pancreatitis, pancreatic tumors and diabetes, and it was first reported in 1911 by Heiberg at autopsy.
Facts
Classification
ICD-10 ChapterXVII: Congenital Malformations, Deformations and Chromosomal Abnormalities 1 Communicable or Non-communicable Causative Agent
Causative Agent (category)Idiopathic / Multifactorial 1 First Described Sources
1. Dorsal pancreatic agenesis (Wikipedia)
Lead section
is a congenital anomaly
Lead section [body-system]
absence of the duct of Santorini, tail and body of the pancreas
Lead section [first-described-year]
First reported in 1911 by Heiberg in an autopsy
Lead - causative-agent
While the cause is unclear, its mechanism is thought to be impaired dorsal buds or mutation of genes that regulate organogenesis during embryogenesis.
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