Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract, arising in the smooth muscle pacemaker interstitial cells of Cajal or similar cells. They are defined by mutations in the KIT gene in about 85 percent of cases, the PDGFRA gene in about 10 percent, or more rarely BRAF kinase, and 95 percent stain positively for KIT. About two thirds occur in the stomach, where they have a lower malignant potential than tumors found elsewhere in the gastrointestinal tract.
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ICD-10 Chapter Communicable or Non-communicable Transmission Route Sources
1. Wikipedia
Wikipedia contributors, Wikimedia Foundation
2. Wikipedia: ICD-10
WikipediaList of chapters, Chapter IIQuote, List of chapters, Chapter II
Neoplasms
3. World Health Organization: Noncommunicable diseases (fact sheet)
World Health OrganizationLead section, transmission-route statement (inferred from disease-category)
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
Main Types section
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
View the Source Gastrointestinal stromal tumor (Wikipedia)
Lead section
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract.
https://en.wikipedia.org/wiki/Gastrointestinal_stromal_tumor, lead section
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. They are defined as tumors whose behavior is driven by mut
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