Muir-Torre syndrome is a rare hereditary, autosomal dominant cancer syndrome thought to be a subtype of hereditary non-polyposis colorectal cancer. People with the syndrome are prone to cancers of the colon and genitourinary tract along with skin lesions such as keratoacanthomas and sebaceous tumors. It is caused by defects in the genes MLH1, MSH2, and, as more recently recognized, MSH6, all of which are involved in DNA mismatch repair.
Facts
Classification
ICD-10 Chapter Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) Sources
1. Wikipedia: Muir-Torre syndrome
WikipediaLead: causative agent category
Muir-Torre syndrome is a rare hereditary, autosomal dominant cancer syndrome that is thought to be a subtype of HNPCC (Lynch syndrome).
Lead section, body-system statement
Individuals are prone to develop cancers of the colon, genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumors.
Lead section, transmission-route statement
Muir-Torre syndrome is a rare hereditary, autosomal dominant cancer syndrome that is thought to be a subtype of HNPCC (Lynch syndrome).
Lead section, body-system statement (digestive)
Individuals are prone to develop cancers of the colon, genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumors.
View the Source 2. Wikipedia: ICD-10
WikipediaList of chapters, Chapter IIQuote, List of chapters, Chapter II
Neoplasms
3. World Health Organization: Noncommunicable diseases (fact sheet)
World Health OrganizationMain Types sectionQuote, Main Types section
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
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