Congenital hereditary endothelial dystrophy, abbreviated CHED, is a corneal endothelial dystrophy that is present from birth. It was once divided into two subtypes, CHED1 and CHED2, until the International Classification of Corneal Dystrophies renamed CHED1 as posterior polymorphous corneal dystrophy in 2015 and kept the name CHED only for the former CHED2. The source describes it as autosomal recessive, with about 80 percent of cases linked to mutations in the SLC4A11 gene, and states that management primarily involves corneal transplantation, usually needed fairly early in life.
Facts
Causative Agent
Causative Agent (category) Sources
1. Congenital hereditary endothelial dystrophy (Wikipedia)
Lead
Congenital hereditary corneal dystrophy (CHED) is a form of corneal endothelial dystrophy that presents at birth.
Genetics
CHED exhibits autosomal recessive inheritance, with 80% of cases linked to mutations in SLC4A11 gene.
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