Megalocornea

Megalocornea is an extremely rare, nonprogressive condition of the eye in which the cornea has an enlarged diameter, reaching or exceeding 13 millimetres. It is thought to have two subforms, one with autosomal inheritance and one that is X-linked, mapped to Xq21.3-q22. The X-linked form is caused by a mutation in the gene CHRDL1, which encodes the protein Chordin-like 1, and men make up roughly ninety percent of cases. Megalocornea may occur alongside other conditions, among them Alport syndrome, Marfan syndrome, Down syndrome, Crouzon syndrome and Parry-Romberg syndrome. This entry follows the lead of the cited English Wikipedia article and is not medical advice.