Howel-Evans syndrome is an extremely rare inherited condition marked by thickening of the skin on the palms of the hands and soles of the feet, a condition known as hyperkeratosis. This familial disease carries a high lifetime risk of esophageal cancer, which is why it is also known as tylosis with esophageal cancer.
Facts
Classification
ICD-10 ChapterXII: Diseases of the Skin and Subcutaneous Tissue 1 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) First Described Sources
1. Wikipedia: ICD-10
WikipediaList of chapters, Chapter XIIQuote, List of chapters, Chapter XII
Diseases of the skin and subcutaneous tissue
2. Wikidata: Howel-Evans syndrome
WikidataWikidata P31/P279 (instance of / subclass of)Quote, Wikidata P31/P279 (instance of / subclass of)
genetic gastro-esophageal disease; rare gastroesophageal disease; autosomal dominant disease; autosomal dominant disease associated with focal palmoplantar keratoderma as a major feature; esophageal cancer; syndrome
3. Howel-Evans syndrome (Wikipedia)
Article textQuote, Article text
The condition is inherited in an autosomal dominant manner, and it has been linked to a mutation in the RHBDF2 gene.
4. Howel-Evans syndrome (Wikipedia)
Lead sectionQuote, Lead section
Howel-Evans syndrome is an extremely rare condition involving thickening of the skin in the palms of the hands and the soles of the feet (hyperkeratosis).
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