McCune-Albright syndrome is a complex genetic disorder affecting the bone, skin, and endocrine systems. It is a mosaic disease that arises from somatic activating mutations in the GNAS gene, which encodes the alpha subunit of the Gs heterotrimeric G protein.
Facts
Classification
ICD-10 ChapterXVII: Congenital Malformations, Deformations and Chromosomal Abnormalities 2 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) First Described Sources
1. Wikipedia
Wikipedia contributors, Wikimedia Foundation
2. Wikipedia: ICD-10
WikipediaList of chapters, Chapter XVIIQuote, List of chapters, Chapter XVII
Congenital malformations, deformations and chromosomal abnormalities
3. Wikipedia: Non-communicable disease
WikipediaInherited/genetic diseases sectionQuote, Inherited/genetic diseases section
Genetic disorders are caused by errors in genetic information that produce diseases in the affected people.
4. Wikipedia: McCune-Albright syndrome
Wikipedialead sentence 1
McCune-Albright syndrome is a complex genetic disorder affecting the bone, skin and endocrine systems.
https://en.wikipedia.org/wiki/McCune%E2%80%93Albright_syndrome, lead section
e-Albright syndrome is a complex genetic disorder affecting the bone, skin and endocrine systems. It is a mosaic disease arising from somatic activating mutations in GNAS, which encodes the alpha-subunit of the Gs heterotrimeric G protein.
Lead section, transmission-route statement
McCune-Albright syndrome is a complex genetic disorder affecting the bone, skin and endocrine systems.
View the Source 5. McCune-Albright Syndrome (Wikipedia)
Lead sectionQuote, Lead section
McCune-Albright syndrome is a complex genetic disorder affecting the bone, skin and endocrine systems.
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