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Intraoperative Electron Radiation Therapy

Oncologic Therapy

Intraoperative electron radiation therapy (IOERT) is the application of electron radiation directly to the residual tumor or tumor bed during cancer surgery. Electron beams are useful for this purpose because, depending on the electron energy chosen, the delivered dose falls off rapidly behind the target site, sparing underlying healthy tissue. IOERT has been called precision radiotherapy because the surgeon has direct visualization of the tumor and can exclude normal tissue from the treatment field while protecting critical structures within and underlying the target volume; one of its advantages is that it can be given at the time of surgery, when microscopic residual tumor cells are most vulnerable to destruction, and it is often used in combination with external beam radiotherapy afterward because doing so results in lower integral doses and shorter overall treatment times.

Facts
Classification
Status
Standard of Care 1
Origin Year
1905 2
Intraoperative Electron Radiation Therapy
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FAQs

Where could patients receive intraoperative electron radiation before portable accelerators existed?

Only in shielded operating rooms or a radiotherapy room.

Before portable linear accelerators were built for this purpose, clinicians could treat these patients only in specially shielded operating rooms, which were expensive to build, or in a radiotherapy room. The second option required moving the anesthetized patient from the operating room to the accelerator for treatment.
Connections

Treats

Source Intraoperative electron radiation therapy (Wikipedia)
Sources
1. Wikipedia
Wikipedia contributors, Wikimedia Foundation
2. Intraoperative electron radiation therapy (Wikipedia)
  • History section
    Spanish and German doctors, in 1905 and 1915 respectively, used intraoperative radiation therapy (IORT) in an attempt to eradicate residual tumors left behind after surgical resection.
  • https://en.wikipedia.org/wiki/Intraoperative_electron_radiation_therapy, lead section
    Intraoperative electron radiation therapy is the application of electron radiation directly to the residual tumor or tumor bed during cancer surgery.
  • Treats: Pancreatic Cancer, Article text, use for Pancreatic Cancer
    IOERT has a long history of clinical applications, with promising results, in the management of solid tumors (e.g., pancreatic cancer, locally advanced and recurrent rectal cancer, breast tumors, sarcomas, and selected gynaecologic and genitourinary malignancies, neuroblastomas and brain tumors.
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