Muckle-Wells syndrome

Muckle-Wells syndrome, abbreviated MWS, is a rare autosomal dominant disease that causes sensorineural deafness and recurrent hives and can lead to amyloidosis. People with it often have episodic fever, chills and joint pain, which is why it is counted as a periodic fever syndrome. The source attributes it to a defect in the CIAS1 gene, which creates the protein cryopyrin. It is closely related to familial cold urticaria and neonatal onset multisystem inflammatory disease; all three involve mutations in the same gene and are grouped under the term cryopyrin-associated periodic syndromes, or CAPS. This record is limited to the source's opening summary and is not medical advice.