Hemoglobin D, written HbD, is a variant of hemoglobin, the protein complex that fills red blood cells. It has been named for the places of its original identification, including D-Los Angeles, D-Punjab, D-North Carolina, D-Portugal, D-Oak Ridge and D-Chicago. Harvey Itano identified D-Los Angeles in 1951, and D-Punjab was later found to be the most abundant type, common among the Sikhs of Punjab in Pakistan and India and in Gujarat. Where normal adult hemoglobin, HbA, has glutamic acid at position 121, this variant has glutamine, and that single substitution can produce conditions from mild hemolytic anemia to fatal genetic anemia. The source lists four presentations: the heterozygous HbD trait, HbD-thalassemia, HbS-D sickle cell disease and, very rarely, homozygous HbD disease. It was the fourth hemoglobin type discovered.
Facts
Classification
ICD-10 ChapterIII: Diseases of the Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism 1 Communicable or Non-communicable Causative Agent
Causative Agent (category) First Described Sources
1. Hemoglobin D (Wikipedia)
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Hemoglobin D-Los Angeles was the first type identified by Harvey Itano in 1951
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The single amino acid substitution can cause various blood diseases
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Depending on the type of genetic inheritance
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Hemoglobin D (HbD) is a variant of hemoglobin, a protein complex that makes up red blood cells.
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