Factor V Leiden is a variant of human factor V that causes an increase in blood clotting, a state known as hypercoagulability. The mutation prevents protein C, an anticoagulant protein that normally inhibits the pro-clotting activity of factor V, from binding to factor V normally, leading to an increased tendency to form abnormal and potentially harmful blood clots. It is the most common hereditary hypercoagulability disorder among ethnic Europeans, and is named after the Dutch city of Leiden, where it was first identified in 1994.
Facts
Classification
Body SystemLymphatic or Immune System 1 ICD-10 ChapterIII: Diseases of the Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism 1 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) First Described Sources
1. Wikipedia: ICD-10
WikipediaList of chapters, Chapter IIIQuote, List of chapters, Chapter III
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
2. Wikipedia: Non-communicable disease
WikipediaNamed examples sectionQuote, Named examples section
NCDs include Parkinson's disease, autoimmune diseases, strokes, heart diseases, cancers, diabetes, chronic kidney disease, osteoarthritis, osteoporosis, Alzheimer's disease, cataracts, and others.
3. Wikipedia: Factor V Leiden
Wikipedialead paragraph
Due to this mutation, protein C, an anticoagulant protein that normally inhibits the pro-clotting activity of factor V, is not able to bind normally to factor V, leading to a hypercoagulable state, i.e., an increased tendency for the patient to form abnormal and potentially harmful blood clots.
Lead section, transmission-route statement
Factor V Leiden is the most common hereditary hypercoagulability (prone to clotting) disorder amongst ethnic Europeans.
View the Source 4. Factor V Leiden (Wikipedia)
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