Hypoprothrombinemia

Hypoprothrombinemia is a rare blood disorder in which too little prothrombin, also called Factor II and made in the liver, is present to allow blood to clot normally. Because prothrombin is central to hemostasis, the deficiency raises the risk of spontaneous bleeding, which can appear in the gastrointestinal tract, inside the skull or in the skin and other superficial tissues. It affects both sexes. The congenital form is inherited in an autosomal recessive pattern and is reported at about one in two million people worldwide, and the condition can also be acquired. Recognized signs include easy bruising, bleeding from the mouth lining, nosebleeds, bleeding into joints and heavy menstrual bleeding. The atlas records the condition as a description of the disorder, not as medical advice.