XMEN disease is a rare genetic disorder of the immune system. The name is an acronym for X-linked MAGT1 deficiency with increased susceptibility to Epstein-Barr virus infection and N-linked glycosylation defect. It is used as an example of how glycosylation, the attachment of sugar chains to proteins, shapes the working of the immune system. The disease is characterized by a low count of CD4 T lymphocytes, severe and chronic viral infections, and defective activation of T lymphocytes. The condition was first described in 2011 by investigators in the laboratory of Michael Lenardo at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health in the United States.
Facts
Classification
Body SystemLymphatic or Immune System 1 ICD-10 ChapterIII: Diseases of the Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism 1 Communicable or Non-communicable Causative Agent
Causative Agent (category) First Described Sources
1. XMEN disease (Wikipedia)
Lead
first described this condition in 2011
Lead [causative-agent-category]
XMEN disease is a rare genetic disorder of the immune system
Lead: disease category
XMEN disease is a rare genetic disorder of the immune system that illustrates the role of glycosylation in the function of the immune system.
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