AL amyloidosis, also known as primary amyloidosis, is the most common form of systemic amyloidosis. It results from malfunctioning antibody-producing plasma cells that generate abnormal immunoglobulin light-chain protein fibers, which misfold and accumulate as amyloid deposits throughout the body. It frequently occurs alongside other plasma cell disorders such as multiple myeloma. The kidneys are involved in 60 to 70 percent of cases and the heart in 70 to 80 percent, with cardiac involvement the leading cause of death; the nervous system, gastrointestinal tract, lungs and skin can also be affected. It is a non-communicable hematologic disorder rather than an infectious disease.
Facts
Classification
ICD-10 ChapterIV: Endocrine, Nutritional and Metabolic Diseases 1 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category)Idiopathic / Multifactorial 2 Sources
1. Wikidata: AL amyloidosis
2. AL amyloidosis (Wikipedia)
Lead paragraph, disease category
AL amyloidosis is not communicable, it is a non-infectious hematologic disorder stemming from abnormal cell production rather than pathogenic transmission.
Lead paragraph, cause
AL amyloidosis results from malfunctioning antibody-producing cells that generate abnormal protein fibers composed of immunoglobulin light chain components.
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