CADASIL, short for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, is the most common form of hereditary stroke disorder. It is thought to be caused by mutations of the NOTCH3 gene on chromosome 19 and belongs to a family of disorders called the leukodystrophies. Its most common clinical manifestations are migraine headaches and transient ischemic attacks or strokes, usually occurring between the ages of 40 and 50, though MRI can detect signs of the disease years before it becomes clinically apparent.
Facts
Classification
ICD-10 ChapterIX: Diseases of the Circulatory System 1 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) Sources
1. Wikipedia: ICD-10
WikipediaList of chapters, Chapter IXQuote, List of chapters, Chapter IX
Diseases of the circulatory system
2. World Health Organization: Noncommunicable diseases (fact sheet)
World Health OrganizationLead section, transmission-route statement (inferred from disease-category)
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
Main Types section
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
View the Source 3. CADASIL (Wikipedia)
lead sentence 1Quote, lead sentence 1
CADASIL or CADASIL syndrome, involving cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, is the most common form of hereditary stroke disorder and is thought to be caused by mutations of the NOTCH3 gene on chromosome 19.
Wikidata: CADASIL
Wikidata Q1022718, class allow-list match (w-wdresolver-0926)View the Source Reader Challenges (0)
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