Photopheresis, also called extracorporeal photopheresis, is a form of apheresis and photodynamic therapy in which blood is separated to isolate the buffy coat of white cells and platelets, chemically treated with the light-sensitizing compound 8-methoxypsoralen, exposed to ultraviolet A light, and then returned to the patient; the treated cells appear to induce a cytotoxic effect on T-cell formation once returned. Introduced in a 1987 New England Journal of Medicine publication, it is now a standard United States Food and Drug Administration therapy for cutaneous T-cell lymphoma, and evidence, though largely observational, suggests it may also help treat graft-versus-host disease and epidermolysis bullosa acquisita when other treatments have failed.
Facts
Origin YearSourced to the subject's own account Photopheresis
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How was photopheresis first introduced?
A 1987 New England Journal of Medicine publication.
Photopheresis was introduced in a 1987 New England Journal of Medicine publication describing treatment involving 8-methoxypsoralen. It is now a standard United States Food and Drug Administration therapy for cutaneous T-cell lymphoma.
Connections
Associated With
Photopheresis is a blood treatment procedure within hematology.
Treats
Source Photopheresis (Wikipedia)
Source Photopheresis (Wikipedia)
Source Photopheresis (Wikipedia)
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1. Wikipedia
Wikipedia contributors, Wikimedia Foundation
2. Photopheresis (Wikipedia)
WikipediaLead section, 1987 NEJM sentence
A 1987 New England Journal of Medicine publication introduced photopheresis involving 8-methoxypsoralen.
https://en.wikipedia.org/wiki/Photopheresis, lead section
In medicine, photopheresis (aka extracorporeal photopheresis or ECP) is a form of apheresis and photodynamic therapy in which blood is subject to apheresis to separate buffy coat (WBC + platelets) from whole blood, chemically treated with 8-methoxypsoralen (instilled into a collection bag or given per os in advance), exposed to ultraviolet light (UVA), and then returned to the patient.
Treats: Lymphoma, Lead: treats Lymphoma
A 1987 New England Journal of Medicine publication introduced photopheresis involving 8-methoxypsoralen., now standard U.S. Food and Drug Administration (FDA) therapy for cutaneous T-cell lymphoma.
Treats: Graft-Versus-Host Disease, Lead: treats Graft-Versus-Host Disease
Evidence suggests that this treatment might help treat graft-versus-host disease, though this evidence is largely observational; controlled trials are needed to support this use.
Treats: Ulcerative Colitis, Lead: treats Ulcerative Colitis
Photopheresis is also an experimental treatment for patients with cardiac, pulmonary and renal allograft rejection, graft-versus-host disease, autoimmune diseases, nephrogenic systemic fibrosis and ulcerative colitis.
In Group: Apheresis and Plasma Exchange, Introduction, sentence 1
In medicine, photopheresis (aka extracorporeal photopheresis or ECP) is a form of apheresis and photodynamic therapy in which blood is subject to apheresis to separate buffy coat (WBC + platelets) from whole blood, chemically treated with 8-methoxypsoralen (instilled into a collection bag or given per os in advance), exposed to ultraviolet light (UVA), and then returned to the patient.
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