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Pachydermoperiostosis

Diseases of the Musculoskeletal System and Connective Tissue

Pachydermoperiostosis, abbreviated PDP, is a rare genetic disorder that affects both bones and skin. It is also known as primary hypertrophic osteoarthropathy and as Touraine-Solente-Gole syndrome. It is mainly characterised by pachyderma, a thickening of the skin, periostosis, an excessive formation of bone, and finger clubbing. The disease affects more men than women and, after onset, stabilises after about five to twenty years, though life can be severely impaired. Symptomatic treatments currently include anti-inflammatory drugs, steroids and surgical procedures. It was first described in 1868 by Friedreich, and Touraine, Solente and Gole distinguished three forms in 1935. This entry follows the lead of the cited English Wikipedia article and is not medical advice.

Facts
Classification
Body System
Integumentary System 1
Body System
Skeletal System 1
Communicable or Non-communicable
Non-Communicable 1
Causative Agent
Causative Agent (category)
Genetic / Hereditary 1
First Described
1868 1
Sources
1. Pachydermoperiostosis (Wikipedia)
  • Lead
    In 1868, PDP was first described by Friedreich
  • Lead [body-system]
    a rare genetic disorder that affects both bones and skin
  • Lead [causative-agent-category]
    is a rare genetic disorder that affects both bones and skin
  • Lead: disease category
    Pachydermoperiostosis (PDP) is a rare genetic disorder that affects both bones and skin.
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