Drugs and Medicinal Substances

Anavip

Various

Anavip is a snake antivenom used to treat envenomation by North American rattlesnakes, officially designated crotalidae immune F(ab')2 (equine) and manufactured by Rare Disease Therapeutics. It is a divalent fragment antigen-binding protein preparation, F(ab')2, derived from the blood plasma of horses immunized with venom from two snake species, Bothrops asper and Crotalus durissus, produced through pepsin digestion of the horse plasma followed by purification to a preparation of more than 85 percent F(ab')2. It is indicated for the management of envenomation from North American rattlesnakes and is a prescription-only medication in the United States.

Facts
Drug Class
Equine-derived antivenin 3
First Approved / Isolated Year
2015 4
Significant Risk
May cause allergic reactions; patients with known allergies to horse protein are particularly at risk for an anaphylactic reaction 3
Source
Biologic 3
Classification
Approval Status
Approved 1
ATC ClassSourced to the subject's own account
V: Various 2
Route of Administration
Intravenous 3
Connections

Long-Form Articles

Sources
1. Anavip (Wikipedia)
  • Lead: approval status
    Anavip is the brand name of a snake antivenin indicated for the management of people with North American rattlesnake envenomation.
  • Route of administration
View the Source
2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code V
Quote, First-level anatomical group codes, Code V
Various
View the Source
3. Anavip (DailyMed prescribing information)
  • Section 1, Indications and Usage
    is an equine-derived antivenin indicated for the management of adult and pediatric patients
  • Section 2, Dosage and Administration
    Infuse intravenously over 60 minutes.
  • Section 11, Description
    is a sterile, lyophilized, polyvalent preparation of equine immunoglobulin F(ab')2 fragments
  • Section 5.1, Hypersensitivity
    Patients with known allergies to horse protein are particularly at risk for an anaphylactic reaction.
View the Source
4. Drugs.com/FDA: Anavip Crotalidae Immune F(ab)2 (Equine) Approval
Approval history
Quote, Approval history
Anavip was FDA approved in 2015 for North American rattlesnake envenomation, not released for distribution until 2018
View the Source
Wikidata: Anavip
Wikidata Q98523655, class allow-list match (w-wdresolver-0926)View the Source
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