A curcuminoid is a linear diarylheptanoid, a relatively small class of plant secondary metabolites that includes curcumin, demethoxycurcumin and bisdemethoxycurcumin, all isolated from turmeric (Curcuma longa). Curcumin is obtained from the root of turmeric. These compounds are natural phenols and give a pronounced yellow color that is often used to color foods and medicines. Curcuminoids dissolve in dimethyl sulfoxide, acetone and ethanol but are poorly soluble in lipids, although their solubility in water-based mixtures can be raised with surfactants or co-surfactants. The most common derivatives carry different substituents on the phenyl groups. Demand is growing for demethoxycurcumin, bisdemethoxycurcumin and the other curcuminoids because of their biological activity. The Medicine Atlas records them as a plant-derived substance class that names no single therapeutic area, and this entry is not medical advice.
Facts
Partially Attested
Approved UseUse in malignant diseases is not justified scientifically, according to a 2023 critical analysis of clinical trials 2 The source is a 2023 critical analysis of clinical trials of curcumin in malignant diseases only. It does not review every use of curcuminoids and does not state a regulatory approval. Drug ClassTurmeric-extracted phytochemicals 1 Mechanism of ActionModulates several molecular pathways and cellular targets involved in tumor initiation, growth, and metastasis 1 Sources
1. Promising anti-tumor properties of bisdemethoxycurcumin: A naturally occurring curcumin analogue (J Cell Physiol, 2018)
Abstract, first sentence
Curcuminoids are turmeric-extracted phytochemicals with documented chemopreventive and anti-tumor activities against several types of malignancies.
Abstract, second sentence
Curcuminoids can modulate several molecular pathways and cellular targets involved in different stages of tumor initiation, growth, and metastasis.
Abstract, first sentence, origin of the compounds
Curcuminoids are turmeric-extracted phytochemicals
View the Source2. Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: critical analysis (Naunyn-Schmiedeberg's Archives of Pharmacology, 2023)
Abstract, concluding sentencesQuote, Abstract, concluding sentences
The available reviews in the literature also do not provide convincing evidence for the efficacy of curcumin. Thus, at the time being, the use of curcumin in malignant diseases is not justified scientifically.
View the Source Curcuminoid (Wikipedia)
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