Amyloidosis

Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. The condition arises from protein misfolding and can be either genetic or acquired. It presents with diverse symptoms depending on the organs affected, commonly including fatigue, swelling of the legs, weight loss, shortness of breath, palpitations, and feeling faint on standing, and in specific types such as AL amyloidosis, patients may develop tongue enlargement and distinctive bruising around the eyes.