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Bone Marrow Transplantation

Oncologic Therapy

Bone marrow transplantation is a form of hematopoietic stem cell transplantation in which multipotent blood-forming stem cells harvested from a donor's or the patient's own bone marrow are infused to replace diseased or destroyed marrow, most often as treatment for leukemia, lymphoma, and other blood cancers or marrow disorders. French oncologist Georges Mathe performed the first successful bone marrow transplants in 1958 in Paris, treating five Yugoslav physicists who had been accidentally irradiated in a nuclear reactor accident, four of whom survived. Transplants may be autologous, using the patient's own stem cells, or allogeneic, using cells from a matched donor.

Facts
Classification
Status
Standard of Care 1
Origin Year
1958 1
Connections

Long-Form Articles

Treats

Bone marrow transplantation is a standard curative treatment for severe aplastic anemia.

Leukemia, Conditions
Sources
1. Wikipedia
Wikipedia contributors, Wikimedia Foundation
  • Bone Marrow Transplantation - Lead section
    Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
  • Bone Marrow Transplantation - History section
    The first successful bone marrow transplants were performed in 1958 by Georges Mathe in Paris on five Yugoslav physicists who had been accidentally irradiated in a nuclear reactor, with four surviving the procedure.
  • https://en.wikipedia.org/wiki/Hematopoietic_stem_cell_transplantation, lead section
    Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
View the Source
Stem-Cell Therapy (Wikipedia)
WikipediaHistory section
Quote, History section
Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology or Medicine.
View the Source
Wikidata: Bone Marrow Transplantation
Wikidata Q1128050, class allow-list match (w-wdresolver-0926)View the Source
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