Sustained Low-Efficiency Dialysis

Sustained low-efficiency dialysis, or SLED, is a hybrid renal replacement therapy that combines features of conventional intermittent hemodialysis and continuous renal replacement therapy. It is delivered using conventional hemodialysis machines run over an extended session, commonly eight to twelve hours, at reduced blood and dialysate flow rates, offering efficient clearance of small solutes with better hemodynamic tolerability than standard intermittent hemodialysis. It is used mainly in intensive care units for critically ill patients with acute kidney injury who are too hemodynamically unstable for conventional hemodialysis, at lower cost and with more flexible scheduling than continuous renal replacement therapy.