T Cell Receptor T Cell Therapy

T cell receptor T cell therapy, abbreviated TCR-T, is a type of adoptive T cell therapy used against some cancers. It works by using and redirecting the T cell receptor, a heterodimer of alpha and beta peptide chains that recognizes fragments of protein presented by the major histocompatibility complex, against a tumor antigen of interest. Unlike chimeric antigen receptor T cell therapy, which targets antigens on the cell surface, TCR-T can recognize the much larger set of intracellular antigen fragments that the major histocompatibility complex presents, though its dependence on that complex also limits where it can be used.