Percutaneous hepatic perfusion

Percutaneous hepatic perfusion is a minimally invasive, regionalized cancer treatment that isolates the liver from the rest of the circulatory system using a catheter and filter system, delivering a chemotherapy drug directly into the liver through the hepatic artery while filtering the venous blood externally before returning it to the jugular vein. Because the treatment confines high doses of chemotherapy to the liver, patients can tolerate substantially larger doses than they could with the same drug given throughout the body, without a corresponding rise in toxicity. It can be repeated and is performed in an operating room or radiology suite under local or general anesthesia, and as of the mid-2020s remained in Phase II and Phase III clinical testing for treating hepatic tumors.