Transarterial chemoembolization, usually abbreviated TACE, is a minimally invasive procedure performed by an interventional radiologist to cut off a tumor's blood supply while delivering chemotherapy directly to it. Small particles coated with a chemotherapy drug are injected through a catheter into the artery that feeds the tumor, where they lodge in place, both blocking blood flow and exposing the tumor to the chemotherapy drug at close range. Although the technique could in principle be applied to tumors in other organs, it is used primarily to treat tumors of the liver, and a related technique that pairs embolization with radioactive particles instead of chemotherapy is called radioembolization or selective internal radiation therapy.
Facts
Disputed
Origin YearMarks the 1972 surgical ligation of the hepatic artery with portal-vein 5-fluorouracil infusion, the precursor procedure the cited source names as the origin from which embolization plus local chemotherapy later developed into transarterial chemoembolization; not a claim about the exact year the combined technique itself was first named or performed. Connections
Sources
1. Wikipedia
Wikipedia contributors, Wikimedia Foundationhttps://en.wikipedia.org/wiki/Transcatheter_arterial_chemoembolization, lead sectionQuote, https://en.wikipedia.org/wiki/Transcatheter_arterial_chemoembolization, lead section
Transcatheter arterial chemoembolization (TACE) is a minimally invasive procedure performed in interventional radiology to restrict a tumor's blood supply.
2. Wikipedia: Transarterial Chemoembolization
WikipediaHistory sectionQuote, History section
In 1972, surgical ligation of the hepatic artery was first used to treat recurrent hepatic tumors followed by infusion of 5-fluorouracil into the portal vein.
Frequently Asked Questions
When did the approach behind transarterial chemoembolization first appear?
The first steps date to 1972 with hepatic artery ligation for recurrent liver tumors.
The roots of the approach go back to 1972, when surgical ligation of the hepatic artery was first used to treat recurrent tumors of the liver, followed by infusion of the chemotherapy drug 5-fluorouracil into the portal vein. Today's procedure is a minimally invasive descendant of that idea: it blocks the artery feeding a tumor while delivering chemotherapy to it through a catheter.
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