Immunoglobulin therapy is the use of a mixture of antibodies drawn from human plasma, called normal human immunoglobulin, to treat a range of health conditions, given by injection into a vein, a muscle or under the skin, with effects lasting several weeks. The therapy dates to the 1930s, initially given by intramuscular injection in the 1950s before an intravenous formulation was approved by the FDA in 1981 and a subcutaneous option became available in the 1990s. It is used to treat primary immunodeficiency, immune thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, Kawasaki disease, Guillain-Barre syndrome and some cases of HIV/AIDS and measles, and is included on the World Health Organization's List of Essential Medicines.
Facts
FAQs
What side effects can immunoglobulin therapy cause?
Mostly injection site pain and allergic reactions; rarely kidney problems or blood clots.
Common side effects include pain at the site of injection, muscle pain and allergic reactions. Severe side effects can include kidney problems, anaphylaxis, blood clots and red blood cell breakdown. Use is not recommended in people with some types of IgA deficiency.
Connections
Sources
1. Wikipedia
Wikipedia contributors, Wikimedia Foundation
2. Wikipedia: Immunoglobulin Therapy
Wikimedia FoundationRoutes of administration, 1950s intramuscular subsection
After immunoglobulin therapy's discovery in 1952, weekly intramuscular injections of immunoglobulin (IMIg) were the norm until intravenous formulations (IVIg) began to be introduced in the 1980s.
Wikipedia: Immunoglobulin Therapy, Routes of administration section (1950s intramuscular subsection)
After immunoglobulin therapy's discovery in 1952, weekly intramuscular injections of immunoglobulin (IMIg) were the norm until intravenous formulations (IVIg) began to be introduced in the 1980s.
https://en.wikipedia.org/wiki/Immunoglobulin_therapy, lead section
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions.
Lead, first sentence
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions.
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