Bone marrow transplantation is a form of hematopoietic stem cell transplantation in which multipotent blood-forming stem cells harvested from a donor's or the patient's own bone marrow are infused to replace diseased or destroyed marrow, most often as treatment for leukemia, lymphoma, and other blood cancers or marrow disorders. French oncologist Georges Mathé performed the first successful bone marrow transplants in 1958 in Paris, treating five Yugoslav physicists who had been accidentally irradiated in a nuclear reactor accident, four of whom survived. Transplants may be autologous, using the patient's own stem cells, or allogeneic, using cells from a matched donor.
Facts
FAQs
What are the main complications of a bone marrow transplant?
Infection and graft-versus-host disease are the major complications of a donor transplant.
Infection and graft-versus-host disease are the major complications of allogeneic transplantation, in which the cells come from a donor. For patients with blood cancers or immune deficiencies, the recipient's immune system is usually suppressed with radiation or chemotherapy before the transplantation.
Connections
Long-Form Articles
Treated By
Source Encyclopedia.com: Severe Combined Immunodeficiency
Source Severe Combined Immunodeficiency, X-Linked (Altmeyers Encyclopedia)
Treats
Bone marrow transplantation is a standard curative treatment for severe aplastic anemia.
Source Bare lymphocyte syndrome type II (Wikipedia)
Sources
1. Wikipedia
Wikipedia contributors, Wikimedia Foundation
Stem-Cell Therapy (Wikipedia)
WikipediaHistory section
Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology or Medicine.
Bone Marrow Transplantation - Lead section
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
Bone Marrow Transplantation - History section
The very first successful bone marrow transplants were performed in 1958 by Georges Mathé, then assistant to Jean Bernard at the Hôpital Saint-Louis in Paris, on five Yugoslav physicists accidentally irradiated in a nuclear reactor. Four survived the transplant.
https://en.wikipedia.org/wiki/Hematopoietic_stem_cell_transplantation, lead section
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
Lead, first sentence
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
View the Source Encyclopedia.com: Severe Combined Immunodeficiency
Encyclopedia.comTreated By: Combined immunodeficiencies, Treatment and managementQuote, Treated By: Combined immunodeficiencies, Treatment and management
The best treatment for SCID is a bone marrow transplant (BMT).
Bare lymphocyte syndrome type II (Wikipedia)
Treats: Bare lymphocyte syndrome type II, Treatment and prognosisQuote, Treats: Bare lymphocyte syndrome type II, Treatment and prognosis
additional treatment options include anti-microbial prophylaxis prior to bone marrow transplant
Severe Combined Immunodeficiency, X-Linked (Altmeyers Encyclopedia)
Treated By: X-linked severe combined immunodeficiency, DefinitionQuote, Treated By: X-linked severe combined immunodeficiency, Definition
usually fatal in the first two years of life unless treated with bone marrow transplantation or gene therapy
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