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Drugs and Medicinal Substances

Cisplatin

Antineoplastic and Immunomodulating Agents

Cisplatin is a chemical compound with formula cis-[Pt(NH3)2Cl2], a coordination complex of platinum used as a chemotherapy medication to treat a number of cancers.

Facts
Drug Class
Platinum-based antineoplastic (chemotherapy) 1
Mechanism of Action
Binds to DNA and inhibits its replication through intrastrand crosslinks with purine bases, triggering DNA repair mechanisms and, when repair fails, apoptosis. 1
Approved Use
Treats a number of cancers, including testicular and ovarian cancer. 1
First Approved / Isolated Year
1978 1
Significant Risk
Bone marrow suppression, hearing problems including severe hearing loss, kidney damage and vomiting. 1
Classification
Approval Status
Approved 1
ATC ClassSourced to the subject's own account
L: Antineoplastic and Immunomodulating Agents 2
Route of Administration
Intravenous 3
WHO Essential MedicineSourced to the subject's own account
Complementary List 4
Connections

Associated With

Chemotherapy, Treatments

Treats

Cancer, Conditions
Source Cisplatin (Wikipedia)
Sources
1. Cisplatin (Wikipedia)
Wikimedia Foundation
  • Lead section
    Cisplatin is a chemical compound with formula cis-[Pt(NH3)2Cl2]. It is a coordination complex of platinum that is used as a chemotherapy medication used to treat a number of cancers.
  • Infobox, drug class
    Platinum-based antineoplastic
  • Mechanism of action section
    formation of intrastrand crosslinks with purine bases
  • History section
    FDA approval came on December 19, 1978
  • Adverse effects section
    Common side effects include bone marrow suppression, hearing problems including severe hearing loss, kidney damage
  • Regulatory approval status
View the Source
2. Anatomical Therapeutic Chemical Classification System (Wikipedia)
WikipediaFirst-level anatomical group codes, Code L
Quote, First-level anatomical group codes, Code L
Antineoplastic and immunomodulating agents
View the Source
3. Cisplatin (Wikipedia)
WikipediaInfobox drug, routes_of_administration
Quote, Infobox drug, routes_of_administration
Intravenous
View the Source
4. WHO Model List of Essential Medicines (Wikipedia)
WikipediaWHO Model List of Essential Medicines, Cytotoxic medicines section
Quote, WHO Model List of Essential Medicines, Cytotoxic medicines section
Cisplatin
View the Source
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