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From STEP to RV 144: what the large HIV vaccine trials showed

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HIV vaccine development (Wikipedia)
Clinical trials, Phase III (RV 144)
Quote, Clinical trials, Phase III (RV 144)
It was discovered that participants receiving vaccines in the RV 144 trial who produced IgG antibodies against the V2 loop of the HIV outer envelope were 43% less likely to become infected than those who did not, while IgA production was associated with a 54% greater risk of infection than those who did not produce the antibodies (but not worse than placebo).
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