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The Sixteen Children Who Proved a Drug Could Fight Cancer

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Sidney Farber (Wikipedia)
Father of modern chemotherapy, Childhood acute lymphoblastic leukemia section
Quote, Father of modern chemotherapy, Childhood acute lymphoblastic leukemia section
In 1947, Farber conducted a clinical trial on aminopterin on 16 children, 10 of whom eventually achieved temporary remission.
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Methotrexate (Wikipedia)
Wikimedia FoundationHistory section
Quote, History section
clinical use of aminopterin was thus abandoned in favor of methotrexate.
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