Alternating hemiplegia of childhood (AHC) is a rare neurological disorder named for transient attacks of hemiplegia, meaning weakness or paralysis, which typically begin before the age of 18 months. An attack can range from mild weakness to complete paralysis on one or both sides of the body, can last for very different lengths of time, and may switch from one side to the other or between one-sided and two-sided involvement within a single episode. Beyond hemiplegia, the disorder brings a very broad and poorly understood range of neurological and developmental impairments. Attacks and their associated symptoms normally stop completely during sleep but may return on waking. Most often AHC is caused by a spontaneous mutation in the ATP1A3 gene. It affects roughly one person in a million and was first characterised in 1971.
Facts
Classification
ICD-10 ChapterVI: Diseases of the Nervous System 1 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) First Described Sources
1. Alternating hemiplegia of childhood (Wikipedia)
Lead section
is a rare neurological disorder
Lead section [causative-agent-category]
Most frequently AHC is caused by a spontaneous mutation in the ATP1A3 gene.
Lead section [first-described-year]
having first been characterized in 1971
lead sentence 1
Alternating hemiplegia of childhood (AHC) is a rare neurological disorder named for the transient episodes, often referred to as "attacks", of hemiplegia (weakness or paralysis) that those with the condition experience.
Lead
Alternating hemiplegia of childhood (AHC) is a rare neurological disorder named for the transient episodes, often referred to as "attacks", of hemiplegia (weakness or paralysis) that those with the condition experience.
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