Angiofibroma of soft tissue

Angiofibroma of soft tissue, abbreviated AFST and also called angiofibroma not otherwise specified, is a rare and recently recognized neoplasm. The World Health Organization placed it among the benign fibroblastic and myofibroblastic tumors in 2020, and it was first described by A. Marino-Enriquez and C.D. Fletcher in 2012. The tumors typically arise in a leg but can occur elsewhere, and they develop in older children and adults, including elderly people. They grow slowly, are often painless, and consist mainly of spindle-shaped cells within a prominent network of blood vessels. In almost all cases the spindle cells carry chromosome abnormalities thought to contribute to their growth. Treatment is usually surgical excision; occasional recurrences at the same site need further surgery, but the tumors do not metastasize and the prognosis is good.