Complete androgen insensitivity syndrome

Complete androgen insensitivity syndrome, or CAIS, is a condition in which the body's cells are completely unable to respond to androgens. The insensitivity becomes clinically significant only in individuals exposed to significant amounts of testosterone at some point in their lives, since the lack of cellular response to androgenic hormones prevents the masculinization of male genitalia in the developing fetus and blocks the development of male secondary sexual characteristics at puberty, while allowing female genital and sexual development to proceed largely without impairment.