Cramp Fasciculation Syndrome

Cramp fasciculation syndrome is a rare disorder of peripheral nerve hyperexcitability that causes muscle twitching, cramping, pain, fatigue, and stiffness, and is considered a more severe relative of the more common and otherwise benign fasciculation syndrome. Most cases have no identified cause, though research points to possible autoimmune and genetic contributions, and the condition tends to be chronic. It is diagnosed through clinical examination together with electromyography, which typically shows fasciculations as the main abnormality, and the anticonvulsant carbamazepine has been found to give moderate symptom relief, with immunosuppressive drugs and plasmapheresis used in some cases.