Autosomal dominant leukodystrophy with autonomic disease

Autosomal dominant leukodystrophy with autonomic disease is a rare neurological condition of genetic origin. It is characterized by gradual demyelination of the central nervous system, the loss of the insulating myelin sheath around nerve fibers, which results in a range of impairments including ataxia, mild cognitive disability and autonomic dysfunction. The name indicates a dominant pattern of inheritance, and the condition belongs to a group of disorders called leukodystrophies, which are defined by abnormalities of the white matter of the nervous system.