Dubin-Johnson syndrome is a rare, benign, autosomal recessive disorder in which conjugated bilirubin is raised in the blood on its own. The classic finding is a black liver, caused by deposition of a pigment similar to melanin. The underlying problem is a reduced ability of liver cells to secrete conjugated bilirubin into the bile, which makes it similar to Rotor syndrome. It is usually without symptoms, although it may be diagnosed in early infancy from laboratory tests, and treatment is not usually needed.
Facts
Classification
ICD-10 ChapterIV: Endocrine, Nutritional and Metabolic Diseases 1 Communicable or Non-communicable Causative Agent
Causative Agent (category) First Described Sources
1. World Health Organization: ICD-10 Version:2019 - E80.6
World Health OrganizationICD-10 2019 category E80.6, Chapter IVQuote, ICD-10 2019 category E80.6, Chapter IV
E80.6 Other disorders of bilirubin metabolism Incl.: Dubin-Johnson syndrome
2. Dubin-Johnson syndrome (Wikipedia)
Lead
is a rare, autosomal recessive, benign disorder that causes an isolated increase of conjugated bilirubin in the serum
Lead: disease category
Dubin-Johnson syndrome is a rare, autosomal recessive, benign disorder that causes an isolated increase of conjugated bilirubin in the serum.
Article text
Pathologists Frank Johnson and Isadore Dubin first described Dubin-Johnson syndrome in 1954.
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