Frontotemporal lobar degeneration is a pathological process that occurs in frontotemporal dementia. It involves progressive degeneration affecting specific brain regions while sparing others, characterized by atrophy in the frontal and temporal lobes with preservation of the parietal and occipital lobes. The pathology involves accumulation of abnormal proteins, particularly tau proteins and TDP-43, and genetic mutations in genes such as C9orf72, progranulin and microtubule-associated protein tau contribute to familial cases, though most cases are sporadic with no identified genetic basis.
Facts
Classification
ICD-10 ChapterVI: Diseases of the Nervous System 2 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category)Idiopathic / Multifactorial 1 Sources
1. Frontotemporal lobar degeneration (Wikipedia)
Lead paragraph
Frontotemporal lobar degeneration (FTLD) is a pathological process that occurs in frontotemporal dementia.
Lead paragraph, cause
The pathology involves accumulation of abnormal proteins, particularly tau proteins and TDP-43 (TAR DNA-binding protein 43).
- Wikipedia intro: Frontotemporal lobar degeneration: neurodegenerative process
View the Source2. Monarch Initiative: Monarch Initiative disease search for Frontotemporal lobar degeneration
Monarch Initiativecross reference (xref) of the matching disease recordQuote, cross reference (xref) of the matching disease record
ICD10CM:G31.0
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