Klinefelter syndrome is a genetic condition in which a male is born with an extra copy of the X chromosome. It can affect physical development, fertility, and hormone levels, though its signs vary widely and many affected individuals are never diagnosed. Common features can include reduced testosterone production, taller than average stature, and reduced fertility.
Facts
Classification
ICD-10 ChapterXVII: Congenital Malformations, Deformations and Chromosomal Abnormalities 2 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) First Described Connections
Associated With
Chromosomal condition (extra X chromosome in males); genetics specialty.
Sources
1. Wikidata: Klinefelter Syndrome
WikidataWikidata P279 (body-system: reproductive)
Subclass of: male infertility due to gonadal dysgenesis
Wikidata P279 (body-system: nervous)
Subclass of: chromosomal anomaly with epilepsy as a major feature
View the Source 2. Wikipedia: ICD-10
WikipediaList of chapters, Chapter XVIIQuote, List of chapters, Chapter XVII
Congenital malformations, deformations and chromosomal abnormalities
3. Wikipedia: Non-communicable disease
WikipediaLead section, transmission-route statement (inferred from disease-category)
Down syndrome and Cystic fibrosis.
Inherited/genetic diseases section
Down syndrome and Cystic fibrosis.
View the Source 4. Klinefelter syndrome (Wikipedia)
- Klinefelter syndrome (KS), also known as 47,XXY, is a chromosome anomaly.
Wikipedia: Klinefelter syndrome, History section
The syndrome was named after American endocrinologist Harry Klinefelter, who in 1942 worked with Fuller Albright and E. C. Reifenstein at Massachusetts General Hospital in Boston, Massachusetts, and first described it in the same year.
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