Leydig cell hypoplasia, also known as Leydig cell agenesis, is a rare autosomal recessive genetic and endocrine syndrome affecting an estimated one in a million people with XY chromosomes. It is caused by the body's inability to respond to luteinizing hormone, the gonadotropin that normally signals the testicles' Leydig cells to produce testosterone and other androgen sex hormones. The condition can manifest as pseudohermaphroditism, hypergonadotropic hypogonadism, reduced or absent puberty, and infertility.
Facts
Classification
ICD-10 ChapterIV: Endocrine, Nutritional and Metabolic Diseases 1 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) Sources
1. Wikipedia: ICD-10
WikipediaList of chapters, Chapter IVQuote, List of chapters, Chapter IV
Endocrine, nutritional and metabolic diseases
2. World Health Organization: Noncommunicable diseases (fact sheet)
World Health OrganizationLead section, transmission-route statement (inferred from disease-category)
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
Main Types section
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
View the Source 3. Leydig cell hypoplasia (Wikipedia)
lead sentence 1Quote, lead sentence 1
Leydig cell hypoplasia (or aplasia) (LCH), also known as Leydig cell agenesis, is a rare autosomal recessive genetic and endocrine syndrome affecting an estimated 1 in 1,000,000 individuals with XY chromosomes.
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