Li-Fraumeni syndrome

Li-Fraumeni syndrome, abbreviated LFS, is a rare hereditary disorder, inherited in an autosomal dominant pattern, that predisposes those who carry it to develop cancer. It is named for the American physicians Frederick Pei Li and Joseph F. Fraumeni Jr., who first recognized it after reviewing the medical records and death certificates of children who had died of the muscle cancer rhabdomyosarcoma. The syndrome is also known by the initials SBLA, standing for sarcoma, breast cancer, leukemia and adrenal gland cancer, the cancers it is best known to cause. The lead of the English Wikipedia article on which this entry is based is short, so this description does not go further than naming the syndrome, its inheritance, its origin in the medical literature and its typical cancers.