Lynch syndrome is an inherited genetic condition that greatly increases a person's lifetime risk of colorectal cancer and several other cancers, including cancers of the endometrium, ovary, stomach and urinary tract. It is caused by an inherited mutation in one of the DNA mismatch repair genes, most commonly MLH1, MSH2, MSH6 or PMS2, which normally correct errors made when DNA is copied; when repair fails, mutations accumulate rapidly in dividing cells. The syndrome is named for the American physician Henry Lynch, who spent decades studying families with a strong hereditary pattern of colorectal cancer, and it was formerly known as hereditary nonpolyposis colorectal cancer. People known to carry a Lynch syndrome mutation are typically offered earlier and more frequent cancer screening, since finding tumors at an early stage substantially improves outcomes.
Facts
Classification
ICD-10 Chapter Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) First Described Sources
1. Wikipedia: Hereditary nonpolyposis colorectal cancer
Wikipedialead sentence 2
HNPCC is synonymous with Lynch syndrome, an autosomal dominant genetic condition that is most commonly associated with a high risk of colon cancer and secondarily most associated with endometrial cancer, as well as ovarian, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin cancers.
Lead section, body-system statement
Lynch syndrome is an inherited genetic condition that greatly increases a person's lifetime risk of colorectal cancer and several other cancers, including cancers of the endometrium, ovary, stomach and urinary tract.
View the Source 2. Wikipedia: ICD-10
WikipediaList of chapters, Chapter IIQuote, List of chapters, Chapter II
Neoplasms
3. World Health Organization: Noncommunicable diseases (fact sheet)
World Health OrganizationLead section, transmission-route statement (inferred from disease-category)
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
Main Types section
The main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.
View the Source 4. Lynch Syndrome (Wikipedia)
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