Mannosidosis is a deficiency in mannosidase, an enzyme. There are two types, alpha-mannosidosis and beta-mannosidosis. Both are related to the lysosome and have similar presentation: the former is caused by defective lysosomal alpha-mannosidase and the latter by defective lysosomal beta-mannosidase. In both cases the defect causes accumulation of oligosaccharides rich in mannose in neural tissue and organ tissue. Both types are known to result from autosomal recessive genetic mutations. This entry records what the source lead supports and is not medical advice; signs, onset, frequency and treatment are left for later depth work.
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1. Mannosidosis (Wikipedia)
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Both alpha- and beta-mannosidosis are known to result from autosomal recessive genetic mutations.
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