MELAS syndrome is one of a family of mitochondrial diseases, alongside conditions such as MIDD, MERRF syndrome, and Leber's hereditary optic neuropathy. It was first characterized under this name in 1984. Like other diseases in this family it is caused by defects in the mitochondrial genome, which is inherited only from the mother, and the most common MELAS-causing mutation is a change in mitochondrial DNA known as m.3243A>G.
Facts
Classification
ICD-10 ChapterVI: Diseases of the Nervous System 1 Communicable or Non-communicable Transmission Route Causative Agent
Causative Agent (category) First Described Sources
1. Wikipedia: ICD-10
WikipediaList of chapters, Chapter VIQuote, List of chapters, Chapter VI
Diseases of the nervous system
2. Wikipedia: Non-communicable disease
WikipediaNamed examples sectionQuote, Named examples section
NCDs include Parkinson's disease, autoimmune diseases, strokes, heart diseases, cancers, diabetes, chronic kidney disease, osteoarthritis, osteoporosis, Alzheimer's disease, cataracts, and others.
3. Wikipedia: MELAS syndrome
WikipediaLead section, transmission-route statementQuote, Lead section, transmission-route statement
MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes) is one of the family of mitochondrial diseases, which also include MIDD (maternally inherited diabetes and deafness), MERRF syndrome, and Leber's hereditary optic neuropathy.
4. National Library of Medicine MeSH: MELAS Syndrome
National Library of Medicine MeSHMeSH tree number C16.320.565.189.535Quote, MeSH tree number C16.320.565.189.535
<http://id.nlm.nih.gov/mesh/D017241> <http://id.nlm.nih.gov/mesh/vocab#treeNumber> <http://id.nlm.nih.gov/mesh/C16.320.565.189.535> .
5. MELAS syndrome (Wikipedia)
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