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Non-alcoholic Fatty Liver Disease

Diseases of the Digestive System

Non-alcoholic fatty liver disease, more recently termed metabolic dysfunction-associated steatotic liver disease, is a type of chronic liver disease. It is diagnosed when there is excessive fat build-up in the liver together with at least one metabolic risk factor, and when increased alcohol intake is also present the related term MetALD is used instead, distinguishing it from alcohol-related liver disease, where alcohol is the predominant cause. The disease may progress to its more inflamed form, which is more likely to lead to complications such as cirrhosis, liver cancer, liver failure, and cardiovascular disease, though it can also regress with a healthy diet, exercise, and medication.

Facts
Classification
Body System
Digestive System 1
ICD-10 Chapter
XI: Diseases of the Digestive System 1
Communicable or Non-communicable
Non-Communicable 2
Transmission Route
Non-Transmissible 2
First Described
1952 2
The article adds that fatty liver was linked to diabetes since at least 1784 and that the name non-alcoholic steatohepatitis (NASH) was defined in 1980 by Jurgen Ludwig; 1952 is recorded here as the article's own first acknowledged case of the non-alcoholic form.
Sources
1. Wikipedia: ICD-10
WikipediaList of chapters, Chapter XI
Quote, List of chapters, Chapter XI
Diseases of the digestive system
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2. Wikipedia: Metabolic dysfunction-associated steatotic liver disease
Wikipedia
  • Wikipedia: Metabolic dysfunction-associated steatotic liver disease, History section
    The first acknowledged case of obesity-related non-alcoholic fatty liver was observed in 1952 by Samuel Zelman.
  • Lead section, disease-category statement
    Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a type of chronic liver disease.
  • Lead section, transmission-route statement
    Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a type of chronic liver disease.
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